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VIDAZA was administered in a subcutaneous dose of seventy five mg/m² everyday for seven days each individual 4 months. The dose was elevated to 100 mg/m² if no advantageous result was noticed after 2 procedure cycles. The dose was lowered and/or delayed depending on hematologic response or evidence of renal toxicity. People in the observation arm were being allowed by protocol to cross in excess of to VIDAZA if they'd improves in bone marrow blasts, decreases in hemoglobin, increases in crimson cell transfusion necessities, or decreases in platelets, or whenever they demanded a platelet transfusion or produced a clinical an infection requiring procedure with antibiotics. For uses of evaluating efficacy, the first endpoint was reaction rate (as defined in Table four).
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Other medication may well connect with azacitidine, which include prescription and about-the-counter medicines, natural vitamins, and herbal merchandise. Notify Every single of the health and fitness treatment vendors about all medicines you utilize now and any medication You begin or halt making use of.
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To the best probable profit, it can be crucial to obtain Every scheduled dose of this medication as directed. For those who skip a dose, Get in touch with your physician to determine a brand new dosing schedule.
This medicine can move into overall body fluids (urine, feces, vomit). For at least forty eight hours right after you get a dose, avoid making it possible for Your entire body fluids to come back into connection with your fingers or other surfaces.
Azacitidine administered to pregnant rats by means of a single intraperitoneal (IP) dose approximating eight% in the suggested human daily dose prompted fetal Demise web and anomalies [see Use in Particular Populations].
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Parenteral drug merchandise need to be inspected visually for particulate make a difference and discoloration ahead of administration, Any time Resolution and container allow.